Motif ID: NANOG{mouse}.p2

Z-value: 1.577


Transcription factors associated with NANOG{mouse}.p2:

Gene SymbolEntrez IDGene Name
NANOG 79923 Nanog homeobox

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NANOGchr12_+_78332610.185.1e-01Click!


Activity profile for motif NANOG{mouse}.p2.

activity profile for motif NANOG{mouse}.p2


Sorted Z-values histogram for motif NANOG{mouse}.p2

Sorted Z-values for motif NANOG{mouse}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NANOG{mouse}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_200395741 3.493 NM_080588
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr1_-_200396328 2.705 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr22_-_28992787 2.599 NM_020530
OSM
oncostatin M
chr11_-_66961709 2.448 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr1_+_159817752 2.413 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr10_+_129735796 2.403 NM_130435
PTPRE
protein tyrosine phosphatase, receptor type, E
chr3_-_52542748 2.378 NM_001134231
NT5DC2
5'-nucleotidase domain containing 2
chr3_-_52542849 2.160 NT5DC2
5'-nucleotidase domain containing 2
chr1_+_159899528 2.057 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr19_-_13074973 1.948 NM_005583
LYL1
lymphoblastic leukemia derived sequence 1
chr17_-_59131194 1.838 LIMD2
LIM domain containing 2
chr6_+_34312906 1.792 HMGA1
high mobility group AT-hook 1
chr6_+_34312633 1.723 HMGA1
high mobility group AT-hook 1
chr7_+_143683365 1.693 NM_005435
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr7_+_150013716 1.664 NM_015660
GIMAP2
GTPase, IMAP family member 2
chr6_+_34312625 1.661 NM_145901
NM_145902
HMGA1

high mobility group AT-hook 1

chr6_+_34312641 1.593 HMGA1
high mobility group AT-hook 1
chr19_-_13074669 1.572 LYL1
lymphoblastic leukemia derived sequence 1
chr6_+_34312979 1.547 HMGA1
high mobility group AT-hook 1
chr6_+_34312667 1.538 HMGA1
high mobility group AT-hook 1
chr19_-_13074513 1.497 LYL1
lymphoblastic leukemia derived sequence 1
chr6_-_32268267 1.496 GPSM3
G-protein signaling modulator 3
chr17_-_59131210 1.464 NM_030576
LIMD2
LIM domain containing 2
chr1_-_25164061 1.445 NM_001031680
RUNX3
runt-related transcription factor 3
chr19_+_3129735 1.424 NM_003775
S1PR4
sphingosine-1-phosphate receptor 4
chr6_+_34312554 1.414 NM_002131
NM_145899
NM_145903
HMGA1


high mobility group AT-hook 1


chr17_-_31441390 1.398 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr7_-_143622188 1.375 ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chrX_-_133758812 1.369 NM_001166599
NM_001166600
NM_001170757
FAM122B


family with sequence similarity 122B


chr5_+_169749068 1.351


chr10_+_70517863 1.341 SRGN
serglycin
chr7_-_143622233 1.340 ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35
chr19_-_43608641 1.328 NM_001146202
NM_001146203
NM_001146204
NM_001146205
NM_001146206
NM_001146207
NM_170604
RASGRP4






RAS guanyl releasing protein 4






chrX_-_118711144 1.317 SEPT6
septin 6
chrX_-_118711088 1.295 SEPT6
septin 6
chr7_-_143523582 1.271 NM_001003702
ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35
chr6_+_34313007 1.268 HMGA1
high mobility group AT-hook 1
chr3_+_52543023 1.204


chr5_-_169749215 1.173 NM_004137
KCNMB1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr6_+_31647854 1.171 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chrX_+_44588192 1.150 NM_022076
DUSP21
dual specificity phosphatase 21
chr19_+_876984 1.143 NM_005224
ARID3A
AT rich interactive domain 3A (BRIGHT-like)
chr16_+_29582480 1.097 SPN
sialophorin
chr1_+_196874867 1.055 PTPRC
protein tyrosine phosphatase, receptor type, C
chr12_-_121753795 1.015 NM_177551
GPR109A
G protein-coupled receptor 109A
chr12_+_56114724 0.992 NM_005538
INHBC
inhibin, beta C
chr6_-_31740645 0.975 NM_033177
GPANK1
G patch domain and ankyrin repeats 1
chr9_-_125070613 0.911 NM_018387
STRBP
spermatid perinuclear RNA binding protein
chr9_-_125070675 0.893 NM_001171137
STRBP
spermatid perinuclear RNA binding protein
chr19_+_40337480 0.884 NM_144779
NM_001164605
FXYD5

FXYD domain containing ion transport regulator 5

chr11_+_120966280 0.845 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr1_-_47468029 0.835 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr1_-_28392966 0.816 NM_001164722
NM_001164721
PTAFR

platelet-activating factor receptor

chr3_+_38363292 0.804 XYLB
xylulokinase homolog (H. influenzae)
chr1_+_172104115 0.783 NM_001122770
NM_032522
ZBTB37

zinc finger and BTB domain containing 37

chr6_-_24827265 0.775 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr11_-_72182291 0.770 NM_006645
STARD10
StAR-related lipid transfer (START) domain containing 10
chr1_-_229181240 0.759 NM_001122835
NM_024525
TTC13

tetratricopeptide repeat domain 13

chr2_-_136590210 0.744 NM_001008540
CXCR4
chemokine (C-X-C motif) receptor 4
chr1_-_172103745 0.723 GAS5
growth arrest-specific 5 (non-protein coding)
chr11_+_817584 0.720 NM_173584
EFCAB4A
EF-hand calcium binding domain 4A
chr3_+_42165740 0.717 TRAK1
trafficking protein, kinesin binding 1
chr16_-_3025542 0.715 NM_001103175
CCDC64B
coiled-coil domain containing 64B
chr17_-_36528113 0.713 NM_033059
KRTAP4-11
keratin associated protein 4-11
chr1_-_229181203 0.709 TTC13
tetratricopeptide repeat domain 13
chr4_-_153820535 0.708 NM_152680
TMEM154
transmembrane protein 154
chr2_+_68815416 0.694 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chrX_+_48427137 0.693 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chrX_-_118711350 0.689 NM_015129
NM_145799
NM_145800
NM_145802
SEPT6



septin 6



chr16_-_45339605 0.689 NM_182493
MYLK3
myosin light chain kinase 3
chr1_+_26728846 0.685 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr5_-_89805866 0.683 MBLAC2
metallo-beta-lactamase domain containing 2
chrX_+_48427103 0.679 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr7_+_128795280 0.677 AHCYL2
adenosylhomocysteinase-like 2
chr1_-_229181229 0.671 TTC13
tetratricopeptide repeat domain 13
chr14_+_22059212 0.667


chr2_+_171381317 0.658 NM_000817
NM_013445
GAD1

glutamate decarboxylase 1 (brain, 67kDa)

chr14_+_22059174 0.657


chr3_+_38363226 0.657 NM_005108
XYLB
xylulokinase homolog (H. influenzae)
chr19_-_55539769 0.652 NAPSB
napsin B aspartic peptidase pseudogene
chr10_+_97879457 0.632 NM_014803
ZNF518A
zinc finger protein 518A
chr14_+_75907442 0.632 NM_004452
ESRRB
estrogen-related receptor beta
chr19_+_47073029 0.621 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr3_-_157054860 0.620 NM_001190992
NM_004733
SLC33A1

solute carrier family 33 (acetyl-CoA transporter), member 1

chr4_-_16509354 0.616 LDB2
LIM domain binding 2
chr3_+_38363299 0.610 XYLB
xylulokinase homolog (H. influenzae)
chr4_-_103485309 0.605 NM_022154
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr7_-_30032649 0.598 NM_017946
FKBP14
FK506 binding protein 14, 22 kDa
chr11_-_56761250 0.585 NM_005161
APLNR
apelin receptor
chr12_-_121767272 0.576 NM_006018
GPR109B
G protein-coupled receptor 109B
chr2_-_142605010 0.576 LRP1B
low density lipoprotein receptor-related protein 1B
chr1_+_196874759 0.573 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr7_-_75876830 0.564 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr6_-_33085290 0.562 HLA-DOA
major histocompatibility complex, class II, DO alpha
chr3_-_49826221 0.554 UBA7
ubiquitin-like modifier activating enzyme 7
chr1_-_205161821 0.553 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr6_-_20320607 0.546 NM_001080480
MBOAT1
membrane bound O-acyltransferase domain containing 1
chr14_+_28305922 0.541 NM_005249
FOXG1
forkhead box G1
chr3_-_52235218 0.539 NM_017442
TLR9
toll-like receptor 9
chrX_-_118711183 0.537 SEPT6
septin 6
chr19_-_18058632 0.534 NM_005535
NM_153701
IL12RB1

interleukin 12 receptor, beta 1

chr10_+_5556923 0.530 NM_005185
CALML3
calmodulin-like 3
chr19_-_47498768 0.529 NM_001145939
NM_001145940
PAFAH1B3

platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)

chr2_+_113591940 0.529 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr19_+_6838576 0.529 NM_001974
EMR1
egf-like module containing, mucin-like, hormone receptor-like 1
chr6_+_31648071 0.528 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr17_+_77289775 0.528 NM_012140
SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr7_-_26206845 0.527 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr13_+_107720206 0.527 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr12_+_7348194 0.526 NM_001080454
ACSM4
acyl-CoA synthetase medium-chain family member 4
chr20_+_35406497 0.525 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr16_+_29582065 0.522 SPN
sialophorin
chr6_-_32929721 0.516 NM_000593
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr19_-_44034797 0.516 NM_001005335
HNRNPL
heterogeneous nuclear ribonucleoprotein L
chr15_+_38923470 0.516 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr9_-_99740243 0.499 NM_197978
HEMGN
hemogen
chr1_+_26728827 0.495 NM_002953
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chrX_+_78087484 0.494 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr10_+_97879645 0.494 ZNF518A
zinc finger protein 518A
chr1_-_111544603 0.479


chr19_-_44618375 0.478 NM_001020
RPS16
ribosomal protein S16
chrX_-_152871351 0.473 HCFC1
host cell factor C1 (VP16-accessory protein)
chr2_-_96351345 0.473


chr1_+_203503214 0.470 TMCC2
transmembrane and coiled-coil domain family 2
chr5_+_41961112 0.464 NM_012176
NM_033484
FBXO4

F-box protein 4

chr10_+_104145421 0.463 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr2_-_174537354 0.462 SP3
Sp3 transcription factor
chr2_+_74914742 0.458 HK2
hexokinase 2
chr13_+_107720475 0.458 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr11_+_125678856 0.455 NM_014026
DCPS
decapping enzyme, scavenger
chr6_-_31812049 0.455 CLIC1
chloride intracellular channel 1
chr1_+_26728839 0.448 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr16_-_31054563 0.447 NM_002773
PRSS8
protease, serine, 8
chr8_-_144583718 0.441 NM_201589
MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr14_-_56342097 0.435 NM_172337
OTX2
orthodenticle homeobox 2
chr11_+_125679151 0.435 DCPS
decapping enzyme, scavenger
chr6_-_31812266 0.432 CLIC1
chloride intracellular channel 1
chrX_-_47815426 0.432 NM_001037735
ZNF630
zinc finger protein 630
chr10_-_134940315 0.429 NM_001109
NM_001164489
NM_001164490
ADAM8


ADAM metallopeptidase domain 8


chr11_-_550706 0.429 NM_173573
C11orf35
chromosome 11 open reading frame 35
chr11_+_2881080 0.427 SLC22A18
solute carrier family 22, member 18
chr4_-_16509446 0.424 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr6_-_31812260 0.421 CLIC1
chloride intracellular channel 1
chr6_-_31812072 0.417 CLIC1
chloride intracellular channel 1
chr5_-_50714836 0.414 LOC642366
hypothetical LOC642366
chr1_-_157313179 0.414 NM_004833
AIM2
absent in melanoma 2
chr4_+_154345039 0.409 NM_015271
TRIM2
tripartite motif containing 2
chr19_+_54776398 0.403 NM_000951
PRRG2
proline rich Gla (G-carboxyglutamic acid) 2
chr11_-_84311867 0.400 DLG2
discs, large homolog 2 (Drosophila)
chr16_+_29582069 0.400 NM_003123
SPN
sialophorin
chr22_+_43527101 0.398 NM_001017526
NM_001198726
NM_181335
ARHGAP8


Rho GTPase activating protein 8


chr14_+_28306633 0.397 FOXG1
forkhead box G1
chr11_+_125679164 0.397 DCPS
decapping enzyme, scavenger
chr2_+_203208064 0.396 NM_173511
FAM117B
family with sequence similarity 117, member B
chr9_-_139084833 0.395 NM_178448
C9orf140
chromosome 9 open reading frame 140
chr4_+_39376058 0.393 NM_001111112
NM_001111113
NM_005339
UBE2K


ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)


chr12_-_6586811 0.389 NM_001273
CHD4
chromodomain helicase DNA binding protein 4
chr6_-_31812251 0.389 CLIC1
chloride intracellular channel 1
chr22_+_25347927 0.386 NM_001886
CRYBA4
crystallin, beta A4
chr19_-_18515280 0.386 FKBP8
FK506 binding protein 8, 38kDa
chr13_+_107719977 0.384 NM_001145645
NM_006573
TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

chr12_-_55013713 0.384 NM_001127460
PAN2
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr2_+_203207912 0.383 FAM117B
family with sequence similarity 117, member B
chr6_+_37081387 0.381 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr5_+_27508139 0.379 LOC643401
hypothetical protein LOC643401
chr4_-_103485419 0.374 NM_001135147
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr13_+_107720561 0.374 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr1_+_246682699 0.372 NM_001004136
OR2T2
olfactory receptor, family 2, subfamily T, member 2
chrX_-_15782792 0.370 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr14_+_22911857 0.366 NM_172314
NM_022789
IL25

interleukin 25

chr18_+_13208777 0.365 NM_181481
NM_181482
C18orf1

chromosome 18 open reading frame 1

chr17_-_46140015 0.363 NM_052855
ANKRD40
ankyrin repeat domain 40
chrX_-_107569256 0.360 NM_001847
COL4A6
collagen, type IV, alpha 6
chr2_-_85435074 0.360 NM_017750
RETSAT
retinol saturase (all-trans-retinol 13,14-reductase)
chr6_-_30760413 0.359 KIAA1949
KIAA1949
chr6_-_32206029 0.358 NM_022110
FKBPL
FK506 binding protein like
chr2_+_64535114 0.358 HSPC159
galectin-related protein
chr10_+_70517823 0.355 NM_002727
SRGN
serglycin
chr10_+_83627422 0.355 NM_001165973
NRG3
neuregulin 3
chr7_+_94953148 0.352 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr11_+_63627816 0.351 NM_013280
FLRT1
fibronectin leucine rich transmembrane protein 1
chr7_+_102502852 0.351 ARMC10
armadillo repeat containing 10
chr21_-_39642935 0.347 HMGN1
high-mobility group nucleosome binding domain 1
chr7_+_143646150 0.346 NM_001005287
NM_001001802
OR2A1
OR2A42
olfactory receptor, family 2, subfamily A, member 1
olfactory receptor, family 2, subfamily A, member 42
chr12_-_6586736 0.345 CHD4
chromodomain helicase DNA binding protein 4
chr5_+_50714996 0.344 ISL1
ISL LIM homeobox 1
chr10_-_48010879 0.341 NM_002900
RBP3
retinol binding protein 3, interstitial
chr3_-_49826360 0.339 NM_003335
UBA7
ubiquitin-like modifier activating enzyme 7
chr8_+_66744659 0.339 NM_001145838
MTFR1
mitochondrial fission regulator 1
chr17_-_40484329 0.338 NM_001128631
DCAKD
dephospho-CoA kinase domain containing
chr14_-_98807307 0.337 BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)
chr3_-_46761248 0.337 NM_199183
PRSS45
protease, serine, 45
chr12_+_45896511 0.336 FAM113B
family with sequence similarity 113, member B
chr6_-_31812283 0.335 CLIC1
chloride intracellular channel 1
chr9_+_138680064 0.334 EGFL7
EGF-like-domain, multiple 7
chr5_+_156625629 0.332 NM_001037333
NM_001037332
CYFIP2

cytoplasmic FMR1 interacting protein 2

chr1_-_224143389 0.332 NM_020997
LEFTY1
left-right determination factor 1
chr17_-_43273537 0.329 SCRN2
secernin 2
chr1_+_111544469 0.325


chr11_-_6773589 0.324 NM_003696
OR6A2
olfactory receptor, family 6, subfamily A, member 2

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
13.49 4.74e-02 GO:0005110 frizzled-2 binding